Name: S-Adenosyl methionine, SAM powder,Ademetionine disulfate tosylate powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Ademetionine disulfate tosylate is a sulfate form of S-Adenosyl methionine (SAM). Compared with S-Adenosyl methionine, Ademetionine disulfate tosylate is easier to store and more stable.

Product Name

Ademetionine disulfate tosylate;S-Adenosyl methionine

Specification

99.9%

Appearance

white powder

CAS No

97540-22-2;485-80-3

Molecular formula

C15H22N6O5S2(H2SO4)C7H8SO3;C15H23N6O5S+

Package

25kg cardboard drum

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Desciption

Product information
What is Ademetionine disulfate tosylate or S-Adenosyl methionine?
Ademetionine disulfate tosylate is a sulfate form of S-Adenosyl methionine (SAM). They are all Joyous products, so we will put them together to facilitate some customers to choose.
Ademetionine Disulfate Tosylate is a bisulfate-toluenesulfonate mixed salt form of the diastereoisomers of SAM ion. Compared with its mixed salt form, SAM is of course higher in purity, but on the contrary, its stability and production time The convenience is far less than its mixed salt counterpart.
As a methyl donor for hundreds of different methylation reactions in the human body, SAM can affect the biosynthesis and metabolism of hormones, neurotransmitters, nucleic acids, proteins and phospholipids in the body, as well as the formation of the antioxidant glutathione, and also interacts with the body Various detoxification processes are closely related and are important life substances indispensable for maintaining the normal function of cell membranes, normal metabolism and health of the human body.

SAM is synthesized from Adenosine triphosphate ATP and methionine under the action of Methionine adenosyltransferase. Transmethylation, transsulfhydration, and aminopropylation all use the S-adenosylmethionine metabolic pathway. These anabolic reactions occur throughout the body, with most production and consumption of S-adenosylmethionine occurring in the liver. The methyl group (CH) attached to the sulfur atom of the methionine in S-adenosylmethionine is chemically active. This allows the methyl group to be easily transferred to the acceptor substrate in a transmethylation reaction. More than 40 metabolic reactions involve the transfer of methyl groups from S-adenosylmethionine to various substrates, such as nucleic acids, proteins, lipids, and secondary metabolites. In bacteria, S-adenosylmethionine is connected to the S-adenosylmethionine ribose switch (SAM riboswitch) and participates in regulating the synthesis of methionine and cysteine.
Joyous Ademetionine disulfate tosylate powder specification

Terms	Standard	Terms	Standard
Product Name	Ademetionine disulfate tosylate / S-Adenosyl methionine（SAM）	Appearance	white powder
Assay	99%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

What are the functions of Ademetionine disulfate tosylate / S-Adenosyl methionine（SAM）powder?
In most methylation reactions in cells, SAM plays an important physiological role and is a methyl donor for reactions catalyzed by more than 100 different methyltransferases in the human body. Many cells contain a large number of specialized SAM transmethylases (which can only accept methyl groups provided by Sam), which can transfer methyl groups on SAM to sulfur, nitrogen, carbon, and oxygen atoms, and participate in the synthesis and metabolism of substances in the body. . DNA methylation is one of the research contents of epigenetics. DNA methylation is a covalent chemical modification catalyzed by DNMTs (DNA methylation transferases), using SAM-e as the methyl donor to remove the 5th carbon atom of the pyrimidine ring of the cytosine nucleotide. Methylated, and forms methylated CpC with its 3-terminal guanine. The role of DNA methylation, simply put, is to serve as a regulatory "switch" for gene expression. For the market, its application is also very promising. Current research shows that NMN will take away methyl groups in the human body. In order to prevent the loss of methyl groups, people taking NMN must use products that supplement methyl groups. For example, currently The very popular ergothioneine, the old product betaine and so on.
DNA methylation plays an important role in regulating individual growth, development, gene expression patterns and genome stability without changing the DNA sequence. At present, oral SAM can be used both as a disease treatment drug and as a dietary supplement. It has good effects on liver disease, depression, arthritis, etc.
Below we briefly introduce the effects of these two products, Ademetionine disulfate tosylate / S-Adenosyl methionine (SAM), on liver disease, depression, and arthritis.

Liver disease
The liver manufactures most of the body's SAM, and the structural and functional integrity of the liver itself is largely dependent on SAM. However, the liver's SAM reserves are also easily depleted by alcohol or various chemical toxins. Under the influence of transmethylation, it can promote the methylation of phospholipids, regulate the flow of liver cell membranes, promote the synthesis of sulfide products in the liver, and reduce the incidence of intrahepatic cholestasis. SAM can transfer the propyl amino group to polyamine, which plays an important role in maintaining the ribosome structure and can effectively promote the proliferation of liver cells. In addition, SAM is also closely related to the levels of glutathione, which is also an important antioxidant and detoxification substance in the liver.

depression
SAM is the main methyl donor in the brain and participates in the synthesis of various neurotransmitters. Due to its transmethylation function, it can promote the metabolism of dopamine, serotonin, norepinephrine, and complex amines in the blood. Methylation of phospholipids helps enhance receptor function, increase receptor density, and improve receptors. coupling effect.

arthritis
The "active sulfur" group contained in SAM can promote the healing of cartilage tissue damage, maintain human bone health, and promote cartilage formation [2]. In addition, SAM supports the biosynthesis of glutathione, cysteine and taurine, which can improve the antioxidant defense of joints, thereby relieving joint stiffness, swelling and pain. In addition, Ademetionine disulfate tosylate / S-Adenosyl methionine (SAM) can also affect the production of sleep factors. The normal production of melatonin by the pineal gland in the brain also requires the participation of SAM.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Ademetionine disulfate tosylate / S-Adenosyl methionine（SAM） powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy Ademetionine disulfate tosylate or S-Adenosyl methionine（SAM） powder?
We offer the best Ademetionine disulfate tosylate or S-Adenosyl methionine（SAM） powder at the most competitive price. Ademetionine disulfate tosylate or S-Adenosyl methionine（SAM） Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Ademetionine disulfate tosylate or S-Adenosyl methionine（SAM） powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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