Name: Fisetin powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Fisetin is a polymer pharmaceutical raw material and a natural flavonoid (a secondary metabolite of plants). As a flavonoid, fisetin not only has direct antioxidant activity, but can also increase glutathione, the main antioxidant in cells. Glypeptide levels. Fisetin maintains mitochondrial function well even under conditions of oxidative stress

Product Name

Fisetin

Specification

95%,98%

Chemical Formula

C15H10O6

Appearance

Yellow powder

CAS No

528-48-3

Packaging

25kg cardboard drum

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Desciption

Product information
What is Fisetin powder?
Fisetin is a polymer pharmaceutical raw material and a natural flavonoid (a secondary metabolite of plants). It belongs to the same flavonol subgroup as quercetin, myricetin and kaempferol and is found in the green parts of plants and fruits. As well as in bark and hardwood, common ones include: fruits (strawberries, apples, persimmons, mangoes, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and grapes. The content of fisetin in strawberries is approximately that in apples. Five times, and generally more than thirty times the content in mango, kiwi, grapes, tomatoes, onions, cucumbers and various nuts
Joyous Fisetin powder specification

Terms	Standard	Terms	Standard
Product Name	Fisetin	Appearance	Yellow powder
Assay	95%,98%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

What are the functions and functions of Fisetin?
1. Antioxidant weapon and inflammation killer
In 1966, an article published in "Nature" stated that fisetin was one of the flavonoids with the strongest antibacterial effect known at the time. It only required 50 μg/ml to effectively inhibit the growth of bacteria such as Staphylococcus aureus. This has attracted scientists' attention to the pharmacological effects of fisetin. In subsequent studies of fisetin, scientists discovered that it has antioxidant and anti-inflammatory effects.
Fisetin, as a flavonoid, is naturally endowed with antioxidant properties. It not only has direct antioxidant activity, but can also increase the level of glutathione, the main antioxidant in cells. Even under oxidative stress, fisetin can well maintain mitochondrial function, and even very fragile neuronal cells can be well protected.
In addition to its own antioxidant talent, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, thereby down-regulating the release of inflammatory cytokines to achieve anti-inflammatory effects.

2. The nemesis of tumors
For the powerful fisetin, antioxidant and anti-inflammatory are actually nothing. They are basic operations. Fighting tumors is its stage. Fisetin plays an inhibitory role at all stages of tumor development, using its "thunderbolt" method to treat tumors docilely.
In the early stages of tumors, fisetin can interfere with chromosome segregation and promote DNA double-strand breaks, thereby reducing its proliferation rate. During the period of rapid tumor growth, fisetin can also reduce the formation of blood vessels by inhibiting uPA (urokinase plasminogen activator) and cut off the tumor's nutritional source. In the late stages of tumors, tumors may metastasize, and fisetin can prevent the degradation of the ECM protein barrier by inhibiting the key target of MMP-1, thereby preventing tumor cells from entering the blood and inhibiting the metastasis of tumor cells.

3. Anti-aging
It is not only cancer that affects human health and longevity, but also aging. Fisetin is not only satisfied with the status quo of suppressing tumors, but also wants to make a contribution in delaying aging.
In 2007, Sinclair and others discovered that fisetin can activate the SIRT1 longevity protein, and fisetin emerged in the anti-aging world. After Dr. James Kirkland proposed the concept of senolytics in 2015, fisetin became a popular senolytics substance due to its powerful ability to eliminate senescent cells, attracting more attention.
Fisetin exerts its powerful anti-aging ability mainly on two points, one as a caloric restriction mimic and the other as a senolytics substance.
Although caloric restriction (CR) has a significant effect in delaying aging, it is a bit painful to implement and the results are slow, which discourages most people. Caloric restriction mimic (CRM) perfectly solves this problem. It can not only simulate CR, but also activate Corresponding signaling pathways without reducing caloric intake.
Fisetin, as a caloric restriction mimetic, induces autophagy by upregulating the expression of SIRT1 in the Sirtuins family, thereby inhibiting mTOR. Unlike other caloric restriction mimetics such as metformin, fisetin is tissue-specific and has a better effect on promoting autophagy in brain cells.
Senolytics Substances
Senolytics refers to the targeted elimination of senescent cells. As people age, senescent cells will continue to accumulate and secrete a large amount of SASP (senescence-associated secretory phenotype), prompting surrounding normal cells to age, thus accelerating the aging of the body.
A 2018 study showed that fisetin had the best effect on clearing senescent cells among the 10 flavonoids at the time. Its effect exceeded that of resveratrol, curcumin, and catechin, so it became the focus of scientists' research. Another study showed that fisetin reduced the mortality rate from nearly 100% to 50% after clearing senescent cells in elderly mice with COVID-19.

So how does fisetin achieve such excellent removal effect? Studies have found that the reason why senescent cells do not undergo apoptosis is that they upregulate the SCAP network (anti-apoptotic pathway), and fisetin blocks the SCAP network by blocking the PI3k/Akt/ mTOR pathway and activating SIRT1 (Anti-apoptotic pathway), thereby causing senescent cells to automatically undergo apoptosis.
As a natural senolytics substance, fisetin has proven its effectiveness and safety in mouse models and human tissues. In terms of clinical aspects, fisetin is currently mainly used for indications such as arthritis, osteoporosis, and new coronary pneumonia. Most of its clinical progress is concentrated in the second phase. It is expected that most clinical results will be released in the second half of this year.

Although the anti-aging clinical trials of fisetin are still ongoing, Joyous is very optimistic about the prospects of fisetin and the field of senolytics it represents, and predicts that this will be a trend from 2024 to 2025. After all, the essence of aging is the accumulation of senescent cells in large quantities, and Senolytics substances can effectively remove senescent cells and achieve the purpose of anti-aging from the root. It is simple, direct and quite effective. Among the many senolytics substances, fisetin has a strong ability to remove senescent cells and is safe. It is undoubtedly a very dazzling new star.
Studies have shown that the human body is very deficient in fisetin and can only absorb about 0.4mg from daily diet. However, if we want fisetin to provide benefits to our body, its recommended daily dose is about 100mg. There is a huge difference between the two. Therefore Joyous believes there is huge market potential for supplementation at this dosage. If we want to rely on fisetin to target senescent cells, the dose must be at least three or four times that dose. Before waiting for clinical results, we might as well lay out some products in the supplement field in advance.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Fullerene powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy Fullerene powder?
We offer the best Fullerenepowder at the most competitive price. Fullerene Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Fullerene powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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