Name: Cycloastragenol powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Cycloastragenol, a triterpenoid saponin compound, is mainly obtained by hydrolysis of Astragaloside IV. Cycloastragenol is the only telomerase activator discovered so far. By increasing telomerase and thereby delaying the shortening of telomeres, cycloastragenol is considered to have anti-aging effects.

Product Name

Cycloastragenol

Appearance

white powder

Specification

98%

CAS No

78574-94-4

Molecular Formula

C30H50O5

Package

25kg cardboard drum

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Desciption

Product information
What isCycloastragenol Powder?
Cycloastragenol is a natural triterpene saponin compound. It is obtained by extracting Astragaloside IV from the dried roots of the leguminous plant Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and finally hydrolyzing it.
Joyous Cycloastragenol powder specification

Terms	Standard	Terms	Standard
Product Name	Cycloastragenol	Appearance	White Powder
Purity	99%	Loss on Drying	≤8%
Total Heavy Metals	≤10 ppm	Ash	≤1%
As	≤0.5ppm	Total Plate Count	≤1000 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Preparation process of Cycloastragenol:
Method 1: Use acid hydrolysis to prepare cycloastraganol. An oxidation reaction is performed before hydrolysis. The oxidation reaction can not only oxidize the sugar part in astragaloside IV to open the chain, but also facilitate subsequent hydrolysis reaction removal without affecting the aglycone part. , thereby increasing the yield of cycloastragalinol. The process flow is: oxidation-reduction-hydrolysis-extraction. The specific operations are as follows: Oxidation and reduction: Take 800 mg of astragaloside IV as raw material, add water to prepare a 0.01mol/L astragaloside IV suspension, and add HCl to adjust the suspension. The pH reaches 4. Add KIO4 to the suspension and react in the dark at 20°C for 48 hours. Then add ethylene glycol to terminate the oxidation. Then add Na2CO3 to pH 7. Concentrate under reduced pressure until there is no alcohol smell. Add an equal volume of n-butanol for extraction. 3 times, combine the n-butanol extraction part, wash with water 2 times, take the n-butanol part, evaporate the n-butanol, and obtain the oxidation product. Add 30% methanol aqueous solution to the oxidation product to disperse into a suspension, in which 30% The mass ratio of methanol aqueous solution and astragaloside IV is 1:1; then add BH4Na as the reducing agent. After 24 hours of reduction reaction, add 50% acetic acid to the pH of the reaction solution to 5 to terminate the reaction, and the reduction product is obtained. Hydrolysis and extraction: Add an appropriate amount of H2SO4 to the reduction reaction solution, and let the reaction stand for 24 hours at 50°C. Add K2CO3 to the hydrolyzed reaction solution, adjust the pH to 7, and then extract three times with an equal volume of ethyl acetate as the reaction solution, and combine The ethyl acetate extract was concentrated under reduced pressure to dryness to obtain crude cycloastragalin. Refining: Dissolve the crude cycloastraganol with an appropriate amount of CH2Cl2-acetone, then place it at 10°C for 2Chemicalbook4h, crystallize, filter and dry to obtain the fine product.
Method 2: A method for preparing cycloastragalinol, including the following steps: oxidation: adding astragaloside IV to a solvent to prepare a suspension with an astragaloside IV content of 0.001-0.05 mol/L; adding acid to adjust the pH of the suspension to 3-6, add oxidant to the suspension, react in the dark at 5-35°C for 12-96 hours, then add ethylene glycol to terminate the oxidation, where the molar ratio of astragaloside IV to oxidant is 1:2-1 :15; then add alkali to adjust the pH to 7-10, concentrate under reduced pressure until there is no alcohol smell, and then filter or extract to obtain the oxidation product; reduction: add the obtained oxidation product to a solvent to disperse it into a solution or suspension; the added solvent The mass ratio to astragaloside IV in step A is 1:0.7-1:40; then add sodium borohydride or potassium borohydride as a reducing agent. After the reduction reaction for 12-48 hours, add acetic acid or acetic acid aqueous solution to adjust the pH of the reaction solution. to 4-6 acidity to terminate the reduction reaction; the molar ratio of the reducing agent to astragaloside IV in step A is 1:2-1:8; hydrolysis: add strong acid to the reaction solution and let it stand or stir at 10-60°C Reaction for 6-96 hours; the mass ratio of the added strong acid to the reaction solution is 0.5-3:100; extraction; add alkali to the obtained reaction solution, adjust the pH to neutral, and then extract with ethyl acetate of the same volume as the reaction solution 3-5 times, combine the ethyl acetate extracts, and concentrate to dryness under reduced pressure to obtain crude cycloastragalinol. Purification: Purify the obtained crude cycloastragalinol using one or more methods of normal phase silica gel column chromatography, reversed phase silica gel column chromatography, and recrystallization to obtain cycloastragalinol.
The role of cycloastragalin
In vivo and in vitro metabolism, in vivo metabolism studies have found that multiple redox metabolites of CAG can be detected in the urine and feces of rats. In the in vitro metabolism investigation of CAG, through the study of enzymatic reaction kinetics and the comparative study of the metabolic capabilities of various tissues in rats, it was found that the metabolism was more obvious in the rat liver. The physical and chemical properties, preparation process, in vivo and in vitro metabolism, and applications of cycloastraganol were edited and compiled by Wang Xu Yan of Chemicalbook. (2016-06-17)
1. Anti-aging: As a telomerase activator, cycloastraganol can delay telomere shortening by increasing telomerase and play an anti-aging effect.
2. Anti-cancer: Anti-cancer auxiliary therapeutic drugs prepared with cycloastragalus as the active ingredient can enhance the efficacy of anti-cancer drugs, reduce the toxicity of anti-cancer drugs, and prevent and treat leukopenia caused by anti-cancer drug treatment. Therapeutic effect.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides cycloastragalin powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules, sachets, and pellets with low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy cycloastragalin powder?
We offer the best cycloastragalin powder at the most competitive price. cycloastragalin Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide cycloastragalin powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, and we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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