Name: Cordycepin powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
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Cordycepin, also known as cordycepin, cordycepin, and cordycepin, is also known as 3′-deoxyadenosine and has the chemical formula C10H13N5O3. It is the first nucleoside antibiotic isolated from fungi. Research results show that cordycepin has biological activities such as lung and kidney protection [2], anti-three highs, anti-tumor [3-4], neuroprotection, anti-inflammatory [5], antioxidant [6] and immune regulation. Therefore, cordycepin has attracted much attention from scholars in the fields of anti-aging, health care, and new drug development.

Product Name

cordycepin

Other Name

cordyceps militaris

Specification

1%,2%,3%,98%

Appearance

Yellow brown powder

CAS No

73-03-0

Packaging

25kg cardboard drum

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Desciption

Product information
What is cordycepin powder?
In the 1950s, wild Cordyceps militaris was discovered in the Changbai Mountain area of Jilin. Studies have confirmed that its ingredients are far more effective than wild Cordyceps sinensis, so it was named Cordyceps sinensis. In 1951, German scientist Cunningham et al. first discovered the core component of Cordyceps militaris, "cordycepin", and discovered its It has a variety of pharmacological activities such as antibacterial, anti-inflammatory, antiviral, anti-tumor and immunomodulation. In the following decades, the academic community carried out a large number of in-depth research on cordycepin. In 1997, the United States has used cordycepin in Phase III Clinical trials are used to treat patients with acute pre-B and pre-T lymphocytic leukemia; in 2017, Professor Wang Chengshu of the Chinese Academy of Sciences published the latest research results on cordycepin online in the Cell sub-journal Cell Chemical Biology: This study completely analyzed the role of cordycepin in The biosynthetic mechanism in Cordyceps militaris, and it was also discovered for the first time that Cordyceps militaris can synthesize the anti-cancer drug Pentostatin. This compound is used to protect the structural stability of the synthesized cordycepin.
Joyous cordycepin powder specification

Terms	Standard	Terms	Standard
Product Name	cordycepin	Appearance	Yellow brown powder
Assay	98%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

What is the main function of cordycepin?
1. Protective effect on lungs and kidneys
Traditional Chinese medicine believes that Cordyceps enters the lung and kidney meridians and can replenish lung yin and kidney yang. It is the only traditional Chinese medicine that can balance and regulate yin and yang at the same time.
In Western medicine research, Ma Shumei and others found that cordycepin can effectively reduce pulmonary fibrosis and improve the lung tissue structure and fibrosis pathological changes. Zhang Min et al. used a rat bronchial asthma model and found that a certain dose of cordycepin inhibited the chronic airway inflammation of asthma. At the same time, combined with glucocorticoids, it can effectively inhibit the contraction of airway smooth muscle, reduce the occurrence of asthma, and treat Remodeling of the airway has a certain improvement effect. Cordycepin intervenes to inhibit the production of cytokines in COPD (chronic obstructive pulmonary disease), while reducing inflammation around lung organs and blood vessels, and alleviating epithelial hyperplasia and other lung pathological changes.
A certain dose of cordycepin can significantly inhibit the fibrosis of interrenal tissue induced by high sugar. The reason is that the high-dose group of cordycepin can enhance the activity of renal antioxidant enzymes, improve glomerular filtration, and reduce the oxidation of the kidneys caused by high blood sugar. Damage, while inhibiting the expression of p-Smad2/3, a key signaling molecule in the TGF-β/Smad signaling pathway, and reducing the expression of collagen and α-SMA in renal tissue to improve renal interstitial fibrosis. At the same time, Wang Zhisen and others found that cordycepin can assist in the treatment of type 2 diabetes, significantly improve patients' immunity and reduce nephrotic proteinuria levels, and improve the survival rate and treatment rate of diabetic nephropathy patients.
2. Anti-three high effects
The three highs are the general term for hyperlipidemia, hypertension, and hyperglycemia. According to research, the clustering of clinical diseases among these three is not accidental, and they influence each other in pairs. Studies have shown that cordycepin has a good blood-lipid-lowering effect, and it also affects fat production while lowering blood-lipids. In 2008, Zhao Haiyan and others found that cordycepin can have a certain protective effect on pancreatic cells under high glucose. In the treatment of early atherosclerosis, cordycepin inhibits the inflammatory response while protecting the integrity of the vascular endothelium.
3. Anti-tumor effect
As one of the most common diseases in humans, cancer has caused people to talk about cancer in a disgraceful way. In recent years, research on the anti-cancer activity and mechanism of action of cordycepin has become a hot topic. Park et al. used Western blotting, a method for measuring protein levels, to measure the anti-tumor activity of cordycepin. In the comparison between the treatment group and the control group, they found that the number of apoptotic cells increased significantly. While cells were apoptotic, C6 glioma cells The migration and invasion abilities of cells were also reduced. Research results indicate that cordycepin may inhibit the proliferation of cancer cells by regulating p85/AKT or GSK3β-r. Kim et al. found that fermented cordycepin mycelium liquid has a stronger inhibitory effect on melanoma. By promoting the expression of Bax apoptosis protein in melanoma cells, it inhibits the proliferation of melanoma.
The inhibitory effect of cordycepin on cancer cells is mostly related to the dosage. Studies have found that cordycepin has an inhibitory effect on the growth of A549 lung cancer and H358 lung cancer cells, and the apoptotic effect of cordycepin on cells is related to the dosage and is dose-dependent. During the study of the mechanism of action, it was found that cordycepin can activate caspases in lung cancer cells, further causing lung cancer cells to undergo apoptosis. Pao et al. found in their research that the inhibitory effect of cordycepin on testicular stromal tumor cells in MA-10 mice is related to the dose and time of action. In the dose- and time-dependent relationship of cordycepin, cordycepin can activate cells. The internal PLC/PKC signal transduction pathway promotes steroid production in MA-10 cells, thereby causing cell apoptosis.
Chen et al. studied the anti-cancer mechanism of cordycepin on CGTHW-2 thyroid cancer cell line and found that cordycepin induced an increase in intracellular calcium levels and activated calpain, which in turn triggered Caspase7 activation and PARP cleavage, leading to apoptosis of cancer cells. The purpose of death. Aramwit et al. found from in vitro mutagenicity and in vivo acute toxicity tests that cordycepin is a non-mutagenic and non-toxic compound and has potential anti-proliferation and anti-migration effects on A549 lung cancer cells. Yifan et al. confirmed the induction effect of cordycepin on neuroblastoma apoptosis through Western blotting. Therefore, cordycepin may become a candidate drug for the treatment of neuroblastoma. Chen et al. found that the combined use of cordycepin and cisplatin can activate the activity of exogenous and endogenous caspases in human oral cancer cell lines, promote the expression of the MAPK pathway, and achieve the effect of promoting cell apoptosis, indicating that cordycepin It may be a potential anticancer agent in combination with cisplatin. Chen Qin et al. found that cordycepin can inhibit rotenone-induced PC12 cell apoptosis and has a potential protective effect. Cordycepin liquid concentration between 1 and 102 μmol·L-1 has a good inhibitory effect on PC12 cell proliferation. The discovery of the anti-tumor effect of cordycepin has taken another step forward in the fight against cancer.
There are only a handful of drugs that can treat tumor diseases and the scope of disease treatment is narrow. Research and development of new anti-tumor drugs are the main tasks in the field of oncology. Cordycepin can inhibit the proliferation of various tumor cells. By studying its mechanism of action and structure-activity relationship, the drug's properties can be improved, thereby inhibiting the proliferation and metastasis of tumor cells in many ways.
4. Neuroprotective and regulatory effects
Cordycepin has neuroprotective and regulatory effects and can effectively protect animal neurons. Jin et al. found that cordycepin can reduce the increase in ROS and Ca2+ levels caused by glutamate, and its anti-apoptotic effect is partially dependent on the activation of adenosine A1 receptor. The results indicate that cordycepin may be a potential therapeutic agent for neuronal diseases. . Chen et al. found that cordycepin has an important neuroprotective effect in hypoxic or ischemic injury. During the study of the electrophysiological mechanism of cordycepin in protecting ischemia and hypoxic injury, it was found that cordycepin (80 μmol/L) can significantly delay hypoxia-induced membrane depolarization, prolong the ability of spontaneous action potential (AP) firing, and delay rapid depolarization occurs. In addition, cordycepin also delayed the decrease in evoked AP amplitude caused by hypoxia. Studies have proven that cordycepin has an important neuroprotective effect against hypoxic injury by improving the electrophysiological function of neurons. Neuroinflammation has been considered a major cause of cerebral hemorrhage and brain damage. Cheng et al. induced cerebral hemorrhage in male mice by stereotactically injecting autologous blood into the body. After successfully inducing cerebral hemorrhage, Cheng et al. administered cordycepin intraperitoneally to the mice and found that cordycepin can significantly relieve neurological symptoms after cerebral hemorrhage. Functional deficits, cerebral edema, and tissue damage surrounding the hematoma. Furthermore, cordycepin improved neuronal death in the hematoma area, indicating that cordycepin plays a neuroprotective role in the intracerebral hemorrhage model. Meng Xuelian et al. found that cordycepin can inhibit the production of NO in microglia and have a protective effect on PC12 neuron cells. It can also protect PC12 cells damaged by H2O2 by increasing SOD activity.
Cardiovascular and cerebrovascular diseases have become one of the most common diseases in humans. Most of the causes are related to the nervous system. Cerebral hemorrhage caused by neurological problems often develops rapidly, and if not treated in time, life will be lost. Research and development of the neuroprotective and regulatory effects of cordycepin can prevent the occurrence of such diseases and reduce the incidence.
5. Anti-inflammatory and antibacterial effects
Cordycepin was first discovered and studied as an antibiotic, and it has a wide range of activities against a variety of pathogenic microorganisms. In the isolation experiment of the anti-inflammatory active component of cerebroside, Chiu et al. found that the biological activity of Cordyceps militaris mainly comes from the content of nucleoside analogues, that is, the content of cordycepin. The methanol solution of the Cordyceps militaris fruiting body showed obvious anti-inflammatory effects. inflammatory activity. Yang et al. treated asthmatic mice with different doses of cordycepin and found that cordycepin can significantly inhibit the signaling pathway, causing excess eotaxin in the alveolar lavage fluid (Bal) of asthmatic mice. Reduce and alleviate inflammatory responses and asthma-related symptoms. Deng Chang and others found that cordycepin can inhibit the expression of pro-inflammatory factors and then promote the expression of anti-inflammatory factors. Su Yan's research found that cordycepin can inhibit the reverse transcriptase activity of human immunodeficiency virus (type) and prevent its infection. The anti-inflammatory effect of cordycepin is expected to play a role in future clinical treatments. The discovery of multiple anti-inflammatory mechanisms allows it to combat more inflammatory problems.
The antibacterial activity and mechanism of action of cordycepin have been extensively studied. After researchers discovered that cordycepin had antibacterial effects in 1951, Cunningham et al. first reported the inhibitory effect of cordycepin on bacteria. They treated 45 strains of Bacillus subtilis with cordycepin and found that the growth of 43 of them was inhibited by cordycepin. Li et al. found that cordycepin has an inhibitory effect on the formation of bacterial colonies in the lungs of infected mice. In experiments, they found that cordycepin enhanced the antibacterial activity of PA-824. Wei Huiping added an acyl chloride to the structural amino position of cordycepin to form a new compound with an amide bond, which also has antibacterial effects. In the study, it was found that cordycepin itself has no effect on Staphylococcus aureus and Candida albicans. Inhibitory effect, but chemically modified cordycepin shows certain antibacterial activity against them. The free amine moiety in C6 of the cordycepin structure is necessary to maintain fungicidal activity. Vodnala et al. inserted a fluorine atom into the C2 position of the cordycepin structure and measured the antibacterial activity of their new product against mice infected with Trypanosoma brucei. They found that cordycepin can inhibit pathogens such as Bacillus anthracis, Streptococcus, and Bacillus mallei. Bacterial survival. Liu Yang et al. explored the optimal concentration of Cordyceps militaris extract against Staphylococcus aureus and found that when the concentration was between 12.5 and 25 mg/mL, Cordyceps militaris extract had a significant antibacterial effect on Staphylococcus aureus. It shows that cordycepin can inhibit the reproduction of a variety of bacteria, fungi, and viruses, which provides a theoretical basis and basic research for future research and development of new drugs.
There are many studies on cordycepin’s antibacterial and anti-inflammatory properties. In future research, scholars can focus on the research on antibacterial and anti-inflammatory preparations of cordycepin. Due to the short half-life and short action time of cordycepin, researchers can prepare cordycepin into a sustained-release preparation to extend the action time in the body and improve the way to maintain the efficacy of multiple and continuous administrations. , scholars can focus on the research on antibacterial and anti-inflammatory preparations of cordycepin. Due to the short half-life and short action time of cordycepin, researchers can prepare cordycepin into a sustained-release preparation to extend the action time in the body and improve the way to maintain the efficacy of multiple and continuous administrations.
6. Immune regulation and antioxidant effects
Cordycepin has a wide range of pharmacological effects. In recent years, research on its immune regulation and antioxidant has been increasing, and its mechanism of action has gradually become clearer. Gao Qing et al. found in in vivo experimental studies that compound Cordyceps militaris granules have the effect of enhancing immunity, which can enhance delayed-type allergic reactions in mice and improve the phagocytic function of monocyte macrophages. Sun Yong et al. used the ear swelling method to determine the antioxidant and immune-regulating effects of Cordyceps militaris ultrafine powder on mice, and found that glutathione peroxidase (GSH-pX) in the mouse liver and GSH-pX in the serum Superoxide dismutase (SOD) was significantly increased, while malondialdehyde (MDA) content in the liver was reduced, indicating that Cordyceps militaris can scavenge free radicals in the body and play an antioxidant role. Zuo Keyuan et al. observed delayed allergic reactions in mice after administration and found that Cordyceps militaris fruiting body micropowder can promote 2,4-dinitrofluorobenzene (DNFB) to induce delayed allergic reactions in mice. , but had no significant effect on the thymus index and spleen index of mice. Cheng Junli et al. found that both Cordyceps militaris and cordycepin aqueous extract from Cordyceps militaris roots have the ability to scavenge free radicals in the body, but the ability of the former to scavenge free radicals is higher than that of the latter. Olatunji et al., while studying the protective effect of cordycepin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity and its underlying mechanisms, found that cordycepin can effectively reduce intracellular malondialdehyde (MDA) content and intracellular reactive oxygen species ( ROS) levels, and significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in 6-OHDA-treated cells, indicating that cordycepin effectively resists Oxidative activity protects PC12 cells from 6-OHDA-induced neurotoxicity.
The fast-paced life in today's society has left many people in a sub-healthy state. Cordycepin's immunomodulatory and antioxidant effects can be used to regulate human metabolism and other issues. Research and develop cordycepin into health products and determine the optimal daily dosage, which can not only enhance immunity but also improve people's sub-health status.
7. The effect of improving sleep
Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive components isolated from the fungus Cordyceps militaris/Cordyceps sinensis. Traditionally, it has been a precious Chinese folk medicine that benefits mankind. Due to the similarity of the chemical structure of adenosine, cordycepin has been focused on various effects in the central nervous system, such as sleep regulation. Therefore, this study aimed to understand whether cordycepin increases natural sleep in rats, and its effect is mediated by adenosine receptors (ARs). After the rats were orally administered cordycepin, their sleep was recorded for 4 hours using electroencephalography. Analysis of sleep structure and brain electrical power spectrum. Cordycepin reduces sleep-wake cycles and increases non-rapid eye movement (NREM) sleep. Interestingly, cordycepin increased theta wave power density during NREM sleep. In addition, after taking cordycepin, the protein levels of AR subtypes (A1, A2A, and A2B) increased, especially in the rat hypothalamus, which plays an important role in sleep regulation. Therefore, we believe that cordycepin increases theta wave power density during NREM sleep in rats through non-specific adrenergic receptors.
8.Others
Cordycepin also has pharmacological activities such as lowering blood sugar and gonadotropin development. Jung et al. have shown that cordycepin stimulates the expression of HNF-1α to activate mouse glucose transporter 2, induces AMPK phosphorylation and gluconeogenesis inhibitory activity, stimulates glucose metabolism to supply cells through glycolysis, and produces energy or converts it into glycogen. to store. Cordycepin could therefore be a potential drug candidate for controlling blood sugar levels because it stimulates glucose uptake and metabolism in liver cells. Wang Hongjun et al. used the accessory gland tissue and organ weight gain method to cut out foreskin glands and levator ani muscles, and found that Cordyceps militaris extract has the tendency to promote the development of accessory gonads and increase the weight of tissues and organs in male castrated rats, and has the biological ability to stimulate testosterone production. effect. Goubran et al. found that cordycepin can inhibit platelets and regulate tumor angiogenesis, growth and metastasis. BorSheng et al. found in the study of cordycepin treatment of leukemia that cordycepin can selectively reduce the stability of b-catenin in leukemia by regulating GSK-3b. The synergy of cordycepin with other therapies could be used as a new idea to eradicate leukemia.
The use of natural herbs has been on the rise in recent years. As one of the main active ingredients in Cordyceps sinensis and Cordyceps militaris, cordycepin has attracted the attention of many scientists. , because it can be obtained through various culture techniques and has unlimited development potential. It is also an excellent bioactive metabolite. Research on the anti-cancer effects of cordycepin is progressing rapidly, and more and more mechanisms of action have been discovered, which also provides opportunities for future anti-cancer drugs. Cancer drug research and development provides new ideas and theoretical foundations. By deeply understanding the mechanism of natural products such as cordycepin on human health and discovering more pharmacological activities, they will have broader development prospects in future pharmaceutical research and development and food and health care industries.

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides cordycepin powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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