After NMN cannot be used in the dietary supplement market in most countries, Australia's NAD+ liposomes, Joyous's NAD+ sustained-release granules, and some local coating technology patents in the United States have appeared one after another. So in terms of products, Where will the differentiation of NR, NAD and NADH, including NMNH, NADP and NADPH be reflected, and how will the market accept Chengdu? This is what we want to say today.
NADH's scientific name is "reduced nicotinamide adenine dinucleotide", commonly known as "mitochondrion", which exists as the precursor of NAD+.
Due to the extremely unstable nature of NADH, it can be directly decomposed into NAD+ and biological hydrogen "H" in the body after ingestion, and releases energy ATP, which not only increases the level of NAD+ in the body, but also supplies energy to cells, and the biological effect utilization rate is quite high. .
Food obtained by the human body is converted into energy. This conversion process goes through a series of biochemical reactions, one of which requires a substance called nicotinamide adenine dinucleotide. This substance has two states - one with a hydrogen ion, called the reduced state, referred to as NADH; one called the oxidized state, without that hydrogen ion, referred to as NAD+. These two states can transform into each other, and a hydrogen ion will be gained or lost during the transformation, which also realizes the transfer of hydrogen ions. Because its role is to cooperate with the action of enzymes, it is also called "Coenzyme I".
Whether it is NR, NMN, NAD and NADH, including NMNH, NADP and NADPH, no matter which form it is, it is ultimately to supplement NAD+. In 2021, American researchers selected 3 substances that are generally believed to be effective in increasing NAD+ levels: NADH, NRH, and NMN conducted research and published the research results in the academic journal "Journal of Functional Foods". It was found that NADH or NRH can significantly increase NAD+ levels. Compared with NMN, NADH can increase NAD+ levels to a greater extent, promote alcohol metabolism, and prevent or treat early liver damage caused by acute alcohol exposure.
Another advantage of NADH is that it is very safe. Drugbank, the world's largest and most complete drug and drug target resource library, has listed NADH among the legal natural nutritional products. There have been more than 20 NADH human safety experiment reports that have been published one after another.
The research history of NADH has exceeded one hundred years. Nobel Prize winner Arthur Harden discovered the existence of NADH as early as 1906. Extensive functional research began in 1930, and clinical treatment trials had begun in 1980. However, despite rich and top-notch theoretical research for more than a hundred years, NADH has not been widely used by humans for a long time.
The reason has been described by the US FDA: In addition to being afraid of light, water, high temperature and oxidation, NADH is also afraid of degradation by gastric acid during the absorption process, making the part that is actually absorbed very limited, and its physical and chemical properties are extremely unstable. The fundamental reasons that limit the widespread application of NADH.
NR is unstable. The supplement currently added is NR-CL, which is the chloride of NR. In the previous production of NMN, it was usually used as the raw material in the previous step. Now NMN is also mainly produced by fermentation. The utilization efficiency in the human body is too low. The advantage is that the price is cheap enough. The current price of Joyous NR-CL is 70 USD/kg and is expected to continue to decline.
The shortcomings of NMN are due to regulatory reasons. After the FDA banned the addition of supplements, the market for NMN was obviously not as good as before. The price of NAD+ is closer to NMN around 2019, which can reach 400 USD/kg. Compared with NADH’s price of 1,700 USD/kg, it is obviously closer to the market. As for the more expensive NADP and NMNH, they may be widely used in price. There will be fewer opportunities.
But one thing to note is that the price of NMN has currently reached about 200 USD/kg. Compared with NMN, the prices of other supplements must be optimized. Here Joyous proposed a sustained-release preparation that reduces costs and increases utilization efficiency. to solve the problem. Hopefully this will help the anti-aging field.
